Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections
نویسندگان
چکیده
منابع مشابه
Secondary Bacterial Infections Associated with Influenza Pandemics
Lower and upper respiratory infections are the fourth highest cause of global mortality (Lozano et al., 2012). Epidemic and pandemic outbreaks of respiratory infection are a major medical concern, often causing considerable disease and a high death toll, typically over a relatively short period of time. Influenza is a major cause of epidemic and pandemic infection. Bacterial co/secondary infect...
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Thyroiditis is an inflammatory condition of the thyroid gland. It has been reported that thyroiditis is currently ranked the third autoimmune disease in the United States and has a staggering estimated prevalence of 21.8/100,000 (Burek et al., 2009). This is a well-established condition and many aspects of its etiology are also well known. According to the 2005 data of the American Thyroid Asso...
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α-defensins are abundant antimicrobial peptides with broad, potent antibacterial, antifungal, and antiviral activities in vitro. Although their contribution to host defense against bacteria in vivo has been demonstrated, comparable studies of their antiviral activity in vivo are lacking. Using a mouse model deficient in activated α-defensins in the small intestine, we show that Paneth cell α-de...
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PURPOSE OF REVIEW Bacterial sepsis is a leading cause of death in the United States, accounting for over 200,000 fatalities annually. Approximately half of bacterial sepsis cases occur following acute respiratory infections, and the lungs are the most common organs to fail. Notably, outbreaks of respiratory viral infections are associated with an increased incidence or severity of bacterial co-...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2011
ISSN: 1931-3128
DOI: 10.1016/j.chom.2011.05.006